Shinichi Hirose Selected Research

Myoclonic Epilepsies (Myoclonic Encephalopathy)

5/2022	The effectiveness of intravenous benzodiazepine for status epilepticus in Dravet syndrome.
6/2020	Establishment of human induced pluripotent stem cells derived from skin cells of a patient with Dravet syndrome.
10/2019	Corrigendum to "Efficacy and tolerability of perampanel in pediatric patients with Dravet syndrome" [Epilepsy Res. 154 (2019) 34-38].
1/2019	Efficacy and tolerability of perampanel in pediatric patients with Dravet syndrome.
1/2018	Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN-mediated editing of the SCN1A gene.
1/2018	Somatic mosaic deletions involving SCN1A cause Dravet syndrome.
1/2017	Rare variants of small effect size in neuronal excitability genes influence clinical outcome in Japanese cases of SCN1A truncation-positive Dravet syndrome.
1/2017	Two mild cases of Dravet syndrome with truncating mutation of SCN1A.
1/2016	SCN8A encephalopathy: Research progress and prospects.
1/2016	Efficacy of antiepileptic drugs for the treatment of Dravet syndrome with different genotypes.

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Shinichi Hirose Research Topics

Disease

39	Epilepsy (Aura) 01/2022 - 01/2002
26	Seizures (Absence Seizure) 01/2020 - 09/2009
20	Myoclonic Epilepsies (Myoclonic Encephalopathy) 05/2022 - 09/2002
9	Benign Neonatal Epilepsy (Benign Familial Neonatal Convulsions) 01/2019 - 09/2002
9	Febrile Seizures (Febrile Seizure) 01/2017 - 06/2002
8	Brain Diseases (Brain Disorder) 01/2019 - 03/2012
7	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 11/2015 - 01/2002
5	Epileptic Syndromes 05/2014 - 11/2004
3	Partial Epilepsies (Epilepsy, Partial) 01/2020 - 01/2015
3	Juvenile Myoclonic Epilepsy 01/2018 - 11/2004
3	succinic semialdehyde dehydrogenase deficiency 02/2012 - 08/2002
2	Status Epilepticus (Complex Partial Status Epilepticus) 05/2022 - 10/2016
2	Ornithine Carbamoyltransferase Deficiency Disease 06/2021 - 04/2006
2	Inflammation (Inflammations) 02/2021 - 01/2015
2	Spasm (Spasms) 01/2020 - 12/2015
2	Infantile Spasms (West Syndrome) 01/2020 - 12/2015
2	Cardiac Arrhythmias (Arrythmia) 02/2019 - 11/2009
2	Frontal Lobe Epilepsy (Epilepsy, Supplementary Motor) 11/2008 - 02/2002
2	Lymphoma (Lymphomas) 11/2008 - 08/2008
2	Generalized Epilepsy with Febrile Seizures Plus 11/2004 - 06/2002
2	Channelopathies 11/2004 - 01/2002
1	Gaucher Disease (Gaucher's Disease) 06/2022
1	Bacterial Infections (Bacterial Infection) 01/2022
1	Temporal Lobe Epilepsy 01/2022
1	Glycogen Storage Disease Type II (Pompe's Disease) 12/2021
1	Mitochondrial complex I deficiency 11/2021
1	Argininosuccinic Aciduria 06/2021
1	Citrullinemia 06/2021
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 04/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2021
1	Chorioamnionitis 02/2021
1	Drug Resistant Epilepsy 01/2020
1	Craniosynostoses (Craniosynostosis) 01/2020
1	Ventricular Tachycardia 02/2019
1	Paralysis (Palsy) 03/2018
1	Tonic-Clonic Epilepsy (Epilepsy, Tonic Clonic) 01/2018
1	Atrophy 05/2017

Drug/Important Bio-Agent (IBA)

12	Anticonvulsants (Antiepileptic Drugs)IBA 05/2022 - 12/2002
11	Sodium Channels (Sodium Channel)IBA 01/2016 - 09/2008
7	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 11/2015 - 01/2002
7	Ion Channels (Ion Channel)IBA 05/2014 - 01/2002
7	GABA-A Receptors (GABA(A) Receptor)IBA 01/2014 - 11/2004
6	Voltage-Gated Sodium ChannelsIBA 01/2018 - 05/2011
5	Phenobarbital (Luminal)FDA Link 05/2022 - 02/2012
5	gamma-Aminobutyric Acid (GABA)IBA 01/2017 - 06/2002
5	Carbamazepine (Tegretol)FDA LinkGeneric 01/2017 - 12/2002
5	Proteins (Proteins, Gene)FDA Link 01/2015 - 04/2006
4	Pharmaceutical PreparationsIBA 10/2020 - 01/2016
4	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2020 - 12/2011
3	Midazolam (Versed)FDA LinkGeneric 05/2022 - 08/2013
3	AcidsIBA 12/2021 - 08/2002
3	NucleotidesIBA 11/2019 - 01/2015
3	Aminobutyrates (Aminobutyric Acid)IBA 01/2017 - 02/2012
3	Amino Acids FDA Link 11/2015 - 04/2006
3	Nonsense Codon (Nonsense Mutation)IBA 03/2014 - 11/2009
2	BenzodiazepinesIBA 05/2022 - 08/2014
2	RNA (Ribonucleic Acid)IBA 11/2021 - 11/2008
2	Biomarkers (Surrogate Marker)IBA 02/2021 - 04/2020
2	perampanelIBA 10/2019 - 01/2019
2	PotassiumIBA 02/2019 - 03/2009
2	Potassium Channels (Potassium Channel)IBA 01/2019 - 01/2017
2	human PRRT2 proteinIBA 01/2016 - 01/2015
2	Adenosine (Adenocard)FDA LinkGeneric 01/2016 - 04/2013
2	Theophylline (Theon)FDA LinkGeneric 11/2015 - 05/2015
2	Valproic Acid (Depakote)FDA LinkGeneric 02/2015 - 07/2003
2	Lamotrigine (Lamictal)FDA LinkGeneric 08/2013 - 12/2011
2	Succinate-Semialdehyde Dehydrogenase (Succinic Semialdehyde Dehydrogenase)IBA 02/2012 - 08/2002
2	4-hydroxybutyric acidIBA 02/2012 - 08/2002
2	GABA Receptors (GABA Receptor)IBA 06/2010 - 09/2002
2	UreaseIBA 07/2003 - 08/2002
1	Glucosylceramidase (Glucocerebrosidase)IBA 06/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	Protein Isoforms (Isoforms)IBA 01/2022
1	EnzymesIBA 12/2021
1	GlycogenIBA 12/2021
1	GlucosidasesIBA 12/2021
1	ArginaseIBA 06/2021
1	Ligases (Synthetase)IBA 06/2021
1	Carbamyl Phosphate (Carbamoyl Phosphate)IBA 06/2021
1	Nuclear RNAIBA 04/2021
1	Carrier Proteins (Binding Protein)IBA 04/2021
1	MicroRNAs (MicroRNA)IBA 02/2021
1	Ribosomal DNA (rDNA)IBA 02/2021
1	Semaphorin-3AIBA 01/2021
1	ras-GRF1 (ras GRF1)IBA 01/2021
1	Small Interfering RNA (siRNA)IBA 06/2020
1	MSX2 proteinIBA 01/2020
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2020
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2020
1	Quinidine (Chinidin)FDA LinkGeneric 02/2019
1	SodiumIBA 02/2019
1	FlunarizineIBA 03/2018
1	Transcription Activator-Like Effector NucleasesIBA 01/2018
1	Isoflurane FDA LinkGeneric 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	Adenosine Triphosphatases (ATPase)IBA 05/2017

Therapy/Procedure

10	Therapeutics 04/2020 - 07/2011
2	Vagus Nerve Stimulation 01/2017 - 12/2013
1	Anesthesia 01/2018